Intratumoral Therapies, 01-R9594

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Principal Investigators
Joseph T. Persyn
Neal K. Vail
Wade Schlameus (SwRI Consultant)
William Phillips (The University of Texas Health Science Center at San Antonio)

Inclusive Dates:  01/01/06 – Current

Background - The objective of this project is to develop radionuclide-containing controlled-release vehicles for the imaging and treatment of solid tumors. What is required is a method to administer and retain a cancer therapy within the solid tumor while permitting local diffusion throughout the tumor mass to achieve a homogeneous treatment. It is envisioned that encapsulated radionuclides will provide increased stability, controlled release, and improved placement of the therapy within the tumor.

Approach - The technical approach is to develop shell material formulations and microencapsulation methods to stabilize radionuclides and to examine their performance in a solid tumor animal model.

Accomplishments - A portable, relatively simple to operate encapsulation system was designed that allowed for the preparation of small quantities of capsules ready for injection in less than one hour. A key technical risk anticipated for this project was to maintain radionuclide stability during encapsulation and provide controlled release from the capsule. Animal studies were conducted to evaluate the injectability and dose distribution of the capsules. The high resolution, nondestructive imaging study indicates that a majority of the encapsulated radionuclide remained at the injection site. This is an improvement compared to the injection of non-encapsulated radionuclides, which diffuse more rapidly throughout the body immediately following injection.

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