Effective Diffusion Coefficients of Solutes through Alginate and ACA Biomatrices

Solute Molecular Wt. (daltons) Dif. Coef. through Alginate (cm2/s) Dif. Coef. through ACA (cm2/s)
Vitamin B12 1,355 2.8 x 10-6 0.51 x 10-6
Insulin 5,800 4.0 x 10-7 0.50 x 10 -7
Myoglobin 24,600 6.6 x 10 -7 0.21 x 10 -7
Albumin 67,500 8.7 x 10 -8 0.92 x 10 -8
The molecular weights and diffusion coefficients of essential nutrients provide a measure of the permeation of each nutrient through a biomatrix. Permeation through an ACA biomatrix was found to decrease with increased molecular weight.

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