cGMP pilot-scale facilities are available for
sample preparation. Custom encapsulation
equipment is often fabricated to meet unique
SwRI scientists used a spray-chilling process to prepare these microspheres.
Several atomization processes are used by Southwest Research Institute (SwRI) staff to solve product performance requirements. Atomization processes include:
- Spinning disk
- Spray drying
- Spray chilling/congealing
Spinning disk is a highly versatile encapsulation process used to prepare matrix morphology and overcoated particles. SwRI staff have innovated the disk process to yield narrow particle size distributions, produce micron-sized particles, and process batch sizes down to a few grams with high recovery efficiency.
Spinning Disk Applications
- Hot melts, prilling, and congealing
- Solvent evaporation
- Water evaporation
- High-solids and high-viscosity feedstocks
Spinning Disk Characteristics
- Particle sizes from 5 µm to 3,000 µm
- Narrow particle size distributions
- Feedstock versatility
- Scalability and high production capacity
- High recovery efficiency
- Continuous production
Spray drying is a traditional atomization process suitable for many feedstocks. Atomization is achieved by nozzle or veined wheels, two-fluid spray nozzles, pressure nozzles, or sonic energy.
Spray Drying Applications
- Water- or solvent-based materials
- Temperature sensitive materials
SwRI scientists use a spray-chilling process to prepare microspheres as shown in the images to the right.
microencapsulation • nanoencapsulation • atomization • spinning disk • spray drying • spray congealing • spray chilling • controlled release