Product Characterization Methods
Micro/Nano Encapsulation

image: SwRI scientists use top-of-the-line molecular modeling systems for applying computational methods in pharmaceutical development to better understand protein and ligand interactions and new compound designs.

SwRI scientists use top-of-the-line molecular modeling systems for applying computational methods in pharmaceutical development to better understand protein and ligand interactions and new compound designs.

 

image:Click image for Micro/Nano Encapsulation brochure.

Using an environmental scanning electron microscope, SwRI scientists are able to image nonconductive samples without extensive sample preparation.

 

image: Environmental scanning electron microscope (ESEM)  images of the SwRI microelectromechanical systems (MEMS) logo.

Environmental scanning electron microscope (ESEM) images of the SwRI microelectromechanical systems (MEMS) logo.

A variety of analytical and physical methods are used by Southwest Research Institute (SwRI) scientists to characterize particles and encapsulated ingredients. SwRI routinely determines:

  • Particle size
  • Payload
  • Content uniformity and stability
  • Active ingredient release profiles and activity
  • Colloid stability
  • Particle stability

Particles

  • Sizing down to 3 nm
  • Powders
  • Dispersions (aqueous and organics)
  • Zeta potential

Particle Morphology

  • Atomic force
  • SEM/EDX (scanning electron microscope/energy-dispersive X-ray spectroscopy)
  • Environmental SEM/STEM [scanning electron microscope (SEM)/scanning-transmission electron microscope (STEM)]
  • Optical microscopy

Thermal Analysis

  • Differential scanning calorimetry
  • Thermal gravimetric analysis
  • Dynamic mechanical analysis

Rheology

  • Low viscosity fluids, gelation and curing profiles, reinforced solid mechanical properties
  • Large dynamic shear range, sub-ambient to >600°C temperature range
  • Multiple frequency waveform generation

Payload/Content

  • HPLC (high performance liquid chromatography)
  • IC, GC (gas chromatography), GC/MS (gas chromatography/mass spectrometry)
  • Fluorescent
  • Thermal gravimetric analysis

Release

  • Dissolution (pH, solvent)
  • Thermal
  • Pressure
  • Simulated body fluids
  • Cell culture
  • Tissue culture

Stability

  • Controlled environment such as:
    • Time
    • Temperature
    • Relative humidity
    • Ultraviolet
    • Acoustic
  • Simulated fluids
  • Thermal and pressure
  • Byproducts

Specialized

  • Biological Safety Laboratory (BSL) 2-4
  • Good Laboratory Practices (GLP)

Related Terminology

microencapsulation  •  nanoencapsulation  •  product characterization  •  particle morphology  •  thermal analysis  •  rheology  •  molecular modeling  •  analytical methods

Benefiting government, industry and the public through innovative science and technology
Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 9 technical divisions.
04/15/14