Chemical Encapsulation Techniques
Micro/Nano Encapsulation

image: Using the SwRI pilot plant equipment and 200-liter reactors, SwRI chemists produce microspheres and synthesize kilogram batches of pharmaceuticals for phase one clinical trials.

Using the SwRI pilot plant equipment and
200-liter reactors, SwRI chemists produce microspheres and synthesize kilogram
batches of pharmaceuticals for phase one
clinical trials. 

 

image: SwRI scientists have developed a novel core material for fluorescent monitoring of microcapsule oxidation.

SwRI scientists have developed a novel core material for fluorescent monitoring of microcapsule oxidation.

 

image: Layer-by-layer deposition adds new properties and stability to existing shell systems.

Layer-by-layer deposition adds new properties and stability to existing shell systems.

 

image: SwRI scientists employ a number of chemical methods to develop highly stable microcapsules as small as 0.1 µm.

SwRI scientists employ a number of chemical methods to develop highly stable microcapsules as small as 0.1 µm.

Chemical encapsulation techniques typically yield particle dispersions that can be used as is or post-processed by other methods, such as spinning disk, spray drying or fluid bed to produce free-flowing powders.

Chemical Encapsulation Techniques

Southwest Research Institute (SwRI) has developed and practices several chemical encapsulation techniques, including:

  • Solvent evaporation
  • In situ polymerization
  • Interfacial polymerization
  • Emulsion polymerization
  • Simple and complex coacervation
  • Layer-by-layer deposition
  • Liposomes

Chemical Application

  • Oil-in-water emulsions
  • Water-in-oil emulsions
  • Core-shell capsules or matrix particles
  • Stable, high-solid dispersions

Chemical Encapsulation Characteristics

  • Particle sizes from about 0.1 micron to 500 microns
  • High payloads
  • Uniform particle size distribution
  • Scalability and high production capacity
  • Batch production

Related Terminology

microencapsulation  •  nanoencapsulation  •  chemical encapsulation techniques  •  polymerization  •  emulsions  •  clinical trials  •  encapsulation  •  particle dispersions

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Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 11 technical divisions.
04/15/14