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BMP-2 Upregulating Compounds for Healing Bone Tissue and Screening Methods for Selecting Such Compounds

Abstract: 

The present disclosure relates to a method to stimulate endogenous BMP-2 up-regulation in a subject which method comprises administering to a subject an effective amount of an H1 receptor antagonist, whereby endogenous BMP-2 up-regulation is stimulated in said subject. Also provided is a pharmaceutical formulation including an H1 receptor antagonist present in an effective amount to stimulate BMP-2 up-regulation in a subject and a kit.

Patent Number: 
9,216,181
Date Of Issue: 
12/22/2015
Inventors: 

Jorge Gianny Rossini