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Oximes for Treatment of Peripheral and Central Nervous System Exposure to Acetyl Cholinestrerase Inhibitors

Abstract: 

The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.

Patent Number: 
8,653,108
Date Of Issue: 
02/18/2014
Inventors: 

Stanton F. McHardy; Richard M. Corbett; Donald M. Maxwell; Michael W. Tidwell; Bismarck Campos; Christopher J. Bemben