Advanced science.  Applied technology.


Apparatus for Preparing Biodegradable Microparticle Formulations Containing Pharmaceutically Active Agents: 7,261,529


This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

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Joseph T. Persyn; Joseph A. McDonough; Neal K. Vail; Darren E. Barlow; Albert M. Zwiener; Eliot M. Slovin