Two Stage Thermal Modulator for Gas Chromatography with Thermally Matched Grounding Point: 8,869,592

Disclosed herein are two stage thermal modulators that are useful in the separation of the components of an analyte sample in an analytical method, such as gas chromatography. In some embodiments, the thermal modulators described herein include a modulator column coupled to at least one ground point so as to define a plurality of stages that may be independently temperature modulated. In some cases, the modulator column (or stages thereof adjacent to a ground point) and the ground point are thermally matched, so as to limit or eliminate the formation of a temperature differential between the modulator column and a ground point.