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Synthesis and Drug Delivery

The Synthesis and Drug Delivery Section in the Chemistry and Chemical Engineering Division develops drug delivery solutions and carries more than 50 years experience in microencapsulation formulation and processing technology. With expertise in analytical and bioanalytical capabilities, SwRI provides the depth of services to expedite drug discovery and development programs. SwRI offers contract research services for formulation development and drug delivery for multiple routes of administration:

  • Intramuscular
  • Subcutaneous
  • Transdermal
  • Nasal
  • Implants

SwRI implements microencapsulation solutions to provide:

  • Dose regulation (targeted release, extended release, improved adsorption, reduced dose frequency)
  • Multiple controlled release mechanisms (dissolution, pH, degradation, diffusion)
  • Stability (oxygen, light, moisture, taste/odor, incompatible ingredients)
  • Kilo- and laboratory-scale synthesis capabilities up to 200 liters
  • Classical chiral resolution
  • Carbohydrate, methacrylate and heterocyclic chemistry
  • Drug Enforcement Administration (DEA) Schedule III-V capabilities

Joseph McDonough, Ph.D., Director

Technical strengths in the section include:

  • More than 50 years of encapsulation and controlled-release expertise
  • Full services from synthesis to preclinical and clinical trial formulations
  • Spray drying and disk atomization
  • Milling and micronization
  • High potency handling
  • Current Good Manufacturing Practice (cGMP) facilities
  • Analytical/bioanalytical method development and validation

Spray Encapsulation of Pharmaceutical Products Brochure

Publications


Microencapsulation and Nanomaterials Department
Chemistry and Chemical Engineering Division
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March 25, 2013