Medicinal & Process Chemistry

image: SwRI scientists use top-of-the-line molecular modeling systems for applying computational methods to aid in understanding protein and ligand interactions and new compound designs.

SwRI's computational chemists employ biostructure-based drug design combined with ligand-based drug design approaches to screen virtual compound libraries in silico as well as optimization of lead series. Applications include discovery of novel ligands for receptors, allosteric binding sites, and enzyme inhibitors.

With more than 20 years of experience in synthesis, medicinal chemistry, and drug development, the Medicinal and Process Chemistry Section of Southwest Research Institute (SwRI) supports our clients' drug development programs from preclinical development through phase II clinical trials.

Computational Drug Design Services

  • In silico protein docking and simulation with proprietary Rhodium™ platform
  • Virtual library screening
  • Allosteric binding site search
  • Pharmacophore model development
  • Accelrys Material Studio®
  • Accelrys Discovery Studio®

Synthetic Services

  • Small molecule library synthesis
  • Automated synthesis and purification
  • Physicochemical characterization
  • Lead development and optimization
  • Protein conjugates
  • High potency compounds

Formulation and Drug Product Services

  • Microencapsulation
  • Customized formulations (liposomes, nanoparticles, etc.)
  • Targeted drug delivery systems
  • cGMP drug product manufacturing

Chemical Process and Analytical Development Services

  • Process scale-up
  • Process evaluation and development
  • Process optimization and critical parameter studies (DoE)
  • Controlled substances
  • High potency drugs
  • Analytical method development and validation
  • Impurity and degradant isolation/synthesis
  • Reference standards
  • cGMP manufacturing for clinical supply
  • ICH stability studies

Project Management

Related Terminology

drug discovery  •  drug development  •  structure-based drug discovery  •  pharmacophore modeling  •  protein docking  •  analog library synthesis  •  protein and peptide conjugates  •  process development  •  analytical development  •  cGMP manufacturing  •  ICH stability studies  •  high potency  •  regulated substances

Benefiting government, industry and the public through innovative science and technology
Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 10 technical divisions.