Medicinal Chemistry/Lead Optimization
Synthesis & Process Chemistry

image: At SwRI, experienced chemists perform multistep synthesis of target compounds using a large variety of synthesis techniques and expertise.

At SwRI, experienced chemists perform multistep synthesis of target compounds using a large variety of synthesis techniques and expertise.

Lead optimization is the process by which the chemical structure of a viable drug lead is modified in an iterative way to generate more active and/or more selective compounds.

Southwest Research Institute (SwRI) pharmaceutical industry-trained scientists offer their wide-ranging drug discovery experiences to assist clients' lead optimization needs. SwRI regularly uses an Accelrys Modeling system with a new Discovery Studio® to carry out structure-based compound design and QSAR studies. Syntheses of a wide variety of structural types have been completed in the Synthesis and Process Chemistry Section, meeting clients' new materials needs.

Related Terminology

lead optimization  •  drug discovery  •  modeling  •  analog synthesis  •  SAR  •  structure activity relationships

Benefiting government, industry and the public through innovative science and technology
Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 11 technical divisions.
11/26/12