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Synthesis and Process Chemistry

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STANTON F. McHARDY, Ph.D.

B.Sc., Chemistry, Texas Lutheran University, 1990
Ph.D., Organic Chemistry, University of Utah, 1996

 

Dr. McHardy is a Manager in the Synthesis and Process Chemistry section focusing on pharmaceutical research and development. The focus of his current work is developing efficient synthesis of organic compounds for SwRI clients in various areas, as well as building and expanding the medicinal chemistry and process chemistry capabilities at SwRI to meet client needs. Dr. McHardy and his SwRI synthesis team have extensive experience in both the large and small-scale synthesis of a number of structurally organic compounds. He also has 10 years' experience as a medicinal chemist and associate director in the neuroscience drug discovery field. He has extensive experience in leading the chemistry strategy for drug discovery programs, as well as utilizing technology-driven medicinal chemistry and computational (in silico) design for the identification of small molecule compounds with CNS drug-like properties. Dr. McHardy is also experienced at utilizing and applying computational chemistry methods and high-speed synthesis techniques to the design of drug-like compounds. He also has experience in managing multidisciplinary teams (chemistry, pharmacology, drug metabolism and toxicology) to deliver high quality clinical candidates in the areas of addiction, schizophrenia, ADHD and cognition. He also has experience working with preclinical and clinical management teams in the preparation of investigator brochures (IBs) and investigational new drugs (INDs). At Pfizer Global Research & Development, he was responsible for leading and managing project teams and the medicinal chemistry strategy for various neuroscience programs.

PROFESSIONAL CHRONOLOGY: Pfizer GR&D/Neuroscience: 1996-2006 [research scientist, 1996-1998, senior research scientist, 1998-2002; senior research investigator, 2002-2004; associate director, 2004-2006]; Southwest Research Institute®: 2006- [senior research scientist, 2006-2007; principal scientist, 2007-2008, Manager-R&D, 2008-present].
 


 

MIKE CORBETT, Ph.D.

B.A., Chemistry, Rice University, 1993
Ph.D., Organic Chemistry, Texas A&M University, 1999

 

Dr. Corbett is a senior research scientist in the Synthesis and Process Chemistry section, where he leads a team of scientists in the identification of viable synthetic routes toward small organic molecules of interest for drug discovery and drug development. Dr. Corbett ensures the on-time delivery of target compounds to clients while meeting agreed-to acceptance criteria. He gained seven years of experience in pharmaceutical research and development while working as a process scientist in Process Research and Development at Bristol-Myers Squibb (BMS) Company. At BMS, he led project teams of approximately 5-10 scientists in the delivery of multi-kilogram quantities of Active Pharmaceutical Ingredients (APIs) to fuel downstream formulation development work, toxicity studies, and clinical studies. Dr. Corbett also led project teams in the development of more efficient synthetic routes toward APIs and has extensive personal experience in the evaluation, design and execution of synthetic routes to small-molecule organic compounds.


PROFESSIONAL CHRONOLOGY: Bristol-Myers Squibb, Process Research and Development: 2001-4 (research investigator, 2001-4; senior research investigator, 2004-8); Southwest Research Institute: research scientist, 2008-2009, Senior Research Scientist 2009-present.
 

For more information about synthesis and process chemistry, or how you can contract with SwRI, please contact Stanton McHardy, Ph.D., at smchardy@swri.org or (210) 522-2669.

 

synchemistry.swri.org

 

Contact Information

Stanton McHardy, Ph.D.

Synthesis and Process Chemistry

(210) 522-2669

smchardy@swri.org

synchemistry.swri.org

Related Terminology

synthesis

medicinal chemistry

drug development

process chemistry

preclinical development

clinical trails

chemical development

custom synthesis

radiolabeled synthesis

medicinal chemistry

lead optimization

computational modeling

analytical capabilities

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Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 11 technical divisions.

February 06, 2012