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Nanoparticles for Drug Delivery to the Central Nervous System

Abstract: 

The present disclosure relates to compositions and methods for producing nanoparticles to provide relatively more rapid delivery of such particles across the blood-brain barrier. The nanoparticles may be formed from bis-quaternary pyridinium-aldoxime salts that may also be of a specific polymorphic structure and which may be formed in either hydrophobic or hydrophilic type liquid media. In addition, the nanoparticle for transport across the blood-brain barrier may comprise a polymeric resin encapsulating a bis-quaternary pyridinium-2-aldoxime salt.

Patent Number: 
9,028,873
Date Of Issue: 
05/12/2015
Inventors: 

Joseph A. McDonoug; Hong Dixon; Larry A. Cabell