Pharmaceutical Salt Forms of Cepharanthine and Tetrandrine

Abstract

The present disclosure relates to the preparation of polymorphic mixtures of Cepharanthine.2HCl. Mixtures of at least two polymorphic forms can be formed into a mobile liquid phase in organic/aqueous solvent mixtures along with enteric polymer that can be spray dried to produce solid particulate enteric formulations for medicinal drug-treatment applications. 

Patent Number
10,576,077
Date Of Issue
Inventors

William E. Bauta; Joseph A. McDonough; Hong Dixon; Stephen T. Wellinghoff; Kevin Fitzpatrick