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Pharmaceutical Salt Forms of Cepharanthine and Tetrandrine: 10,576,077

Abstract: 

The present disclosure relates to the preparation of polymorphic mixtures of Cepharanthine.2HCl. Mixtures of at least two polymorphic forms can be formed into a mobile liquid phase in organic/aqueous solvent mixtures along with enteric polymer that can be spray dried to produce solid particulate enteric formulations for medicinal drug-treatment applications. 

Patent Number: 
10,576,077
Date Of Issue: 
03/03/2020
Inventors: 

William E. Bauta; Joseph A. McDonough; Hong Dixon; Stephen T. Wellinghoff; Kevin Fitzpatrick