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Microbial Forensics & Homeland Security

Forensic microbiology uses cutting-edge technology and expertise to address the threat of dangerous pathogens. Southwest Research Institute (SwRI) has designed and developed test-bed platforms for efficacy evaluations, device performance validation, detection, and decontamination studies in our forensic microbiology laboratory. Nonpathogenic simulants are used for pathogen studies, such as fowlpox to simulate Variola major and Bacillus thuringiensis to represent Bacillus anthracis (anthrax), to evaluate both pro-active source eliminations and post-event scenarios. In addition to decontamination, agent attribution and detection in the environment continues to be a program area focus.

Microbial Forensics Research for Homeland Security

The laboratory’s primary areas in homeland security and microbial forensics include:

Ricin and Botulinum toxin detector testing performed under the biological safety cabinet and with specialized personal protective equipment

Ricin and Botulinum toxin detector testing performed under the biological safety cabinet (BSC) and with specialized personal protective equipment (PPE).

  • Decontamination studies in the following categories:
    • Organisms:
      • Bacterial
      • Toxin
      • Viral
      • Fungal
  • Growth Study Culture Vessels
    • Egg culture
    • Spinner flask
    • Roller bottles
    • Traditional cell culture T-flasks
    • Assay plates
    • Growth vials
    • Fermenters/Bioreactors
  • Bioaerosol testing
  • Technology demonstration and evaluation
  • Molecular biology techniques
    Polymerase chain reaction (PCR) assay to detect a Francisella novicida strain developed as a Tularemia vaccine.

    Polymerase chain reaction (PCR) assay to detect a Francisella novicida strain developed as a Tularemia vaccine.

    • Enzyme-linked immunosorbent assay (ELISA)
    • Polymerase chain reaction (PCR), real-time PCR, and DNA quantification

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